Acetaminophen/Hydrocodone - Can this medication,have Side effects in your sex life?

Absolutely, most all pain medications will have an effect for both men and women. Men are more likely to have issues achieving orgasm or at least a less pleasurable orgasm be it through sex or masturbation. I would suggest taking it easy while on pain medication if you have any heart or anxiety history because as I know from experience, it can be a bad combination.

Yes, all pain meds can.