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Acetaminophen / hydrocodone User Reviews & Ratings (Page 3)

Brand names: Xodol Zyfrel

Acetaminophen / hydrocodone has an average rating of 6.0 out of 10 from a total of 1,285 reviews on Drugs.com. 51% of reviewers reported a positive experience, while 35% reported a negative experience.

Reviews for Acetaminophen / hydrocodone

  • JPano
  • September 12, 2020

Norco (acetaminophen / hydrocodone) for Back Pain "For years I took brand Norco (acetaminophen/hydrocodone) when it was manufactured by Watson. When the drug went off patent, many companies jumped in to manufacture generic versions of the drug. At one time, Watson was manufacturing a generic, which was great, since it was exactly the same as the brand, but Watson was bought out, and it's impossible to know (except through trial and error) whether the purchaser is using the Watson "recipe." As for generics acetaminophen with hydrocodone, for me, the generic Norco manufactured by Aurobindo has been excellent, as has that manufactured by Mallinckrodt and Rhodes. I have also been able to take the generic manufactured by Tris with what is usually adequate pain relief (but not as good as Aurobindo, Mallinckrodt or Rhodes). The generic that I absolutely cannot take is Amneal - it's like not taking anything at all. I'm not sure why, as all of these drugs should have the same amount of opiate in them, but I might as well not fill the prescription if the generic is Amneal."

9 / 10
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106 Report
  • Jillyn
  • Taken for less than 1 month
  • April 4, 2020

For Pain "My GYN prescribed this for me on 4/2/20, for ovarian cysts as he's done a couple of other times in the past, when the ER doesn't want to help with pain control. I'm in pain management & despite my pain Dr ok'ing me receiving pain meds in emergency situations, from Dr's other than him, some ER Dr's don't want to be bothered with my quality of life & doing the right thing . In the past, I'm not sure who the manufacturer was, but, it was effective. With this particular brand, Mallinckrodt, it's not as effective & I've noticed it feels like I've taken some sort of sedative. This hasn't happened before & when I looked this up & found these reviews, I knew I had to share my experience. I also looked up Mallinckrodt & read where they've been in some legal trouble for ethical behavior concerning another one of their meds, so, I wouldn't be surprised if they weren't putting the correct doses of ingredients in these."

3 / 10
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113 Report
  • BB97
  • June 3, 2021

For Pain "I have severe 50 degree upper scoliosis and 40 degree lower scoliosis. I've used Par/Qualitest brand 10/325 and it worked awesome. This Mallinckrodt brand of acetaminophen and hydrocodone is awful!!! I agree with EVERYONE on this comment. We NEED PAR/QUALITEST brand back and dump Mallinckrodt!!! Now because of all the pain pills being wrongly used by people, us poor suffering people with proof of our conditions, we are SUFFERING!!! Something has got to change!! We NEED relief and Mallinckrodt brings none!!! Wheres Qualitest???"

10 / 10
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88 Report
  • Charz
  • March 8, 2020

For Back Pain "Yeah I'm on this Malkincrodt acetaminophen/hydrocodone 10-325 for a bad back. Ex-contractor. This brand feels like completely worthless fake pills. Sick of sitting here in pain. Someone needs to sue these jerks. I asked the pharmacy. There's no other brands they carry. Because they want control of your life! I'm sick of it!"

1 / 10
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114 Report
  • Real...
  • Taken for 2 to 5 years
  • September 13, 2021

Norco (acetaminophen / hydrocodone) for Pain "With brand Norco or Watson Hydrocodone at one a day I experienced occasional itchy nose, occasional mild nausea, occasional constipation. Now at six mallinckrodt brand hydrocodone I have no side effects? Along with minimal pain relief.. Billions of dollars are being spent on these inferior drugs. Peoples money, insurance companies, tax payers money in the trash and people suffering! What a joke the FDA is. Time for a federal lawsuit against the FDA and Mallinckrodt as well as anyone else who stood by while this is going on. This is not the solution to a few bad apples that misuse/abuse their medication. There are much more people who have been using it responsibly and it's not hard to decipher the addicts from the people who want to be able to live their lives without agony and depression from constant pain. It may be sad when abusers overdose but it's worse when honest deserving patients give up due to no pain relieve ."

1 / 10
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81 Report

Are you taking this medicine?

  • Hermit
  • Taken for 5 to 10 years
  • January 7, 2019

Norco (acetaminophen / hydrocodone) for Pain "I just took my last Watson yesterday . I was concerned about continuing this medication because all the pharmacies in my area only stock mallinkrodt and that manufacturers brand causes me increased pain and muscle tension. I consider it to be a substandard medication and really I will not use it. I was lucky to find one pharmacy that stock amneal, while not quite as good as Watson, Amneal is an improvement over Mallinckrodt (mallincrap) so I won't have to ask my doctor to take me off this medication which I was going to do if only mallincrap was available. I have informed my pharmacy that I do not want anything from mallinkrodt as I do not trust this company. Unfortunately they own many of the corporate pharmacies around the country"

5 / 10
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136 Report
  • M 367
  • April 21, 2022

Norco (acetaminophen / hydrocodone) for Pain "It pains me to see my mother suffer, to have been naive enough that I believed all generics are created equal and to have accused her of addiction and abusing her medicine. For a 10 month period in 2021 she had a better generic and her emotional, physical and social health exceeded what I had assumed possible. Now back on bad genetics she is yellow, lethargic and incoherent as well as needing more to ease pain. FDA do your job you’re damaging my mother"

1 / 10
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66 Report
  • G037
  • Taken for less than 1 month
  • November 25, 2022

Lortab (acetaminophen / hydrocodone) for Back Pain "I changed pharmacies from Walgreens to CVS. I had my prescription filled and it’s a different brand G037 acetaminophen/hydrocodone. This brand is making me sick. I was taking M367 acetaminophen/hydrocodone and it worked well, just enough to get me through the day. They need to fix this because people will want to move up to something stronger. Something definitely is wrong with medicine."

1 / 10
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50 Report
  • BoraB...
  • February 27, 2019

For Back Pain "The real truth! They're messing with your pain pills America! Pain pills are completely different than what they used to be. They're changing them to prevent abuse. In turn now they're not working. Every brand is doing it. This is why you can't find relief anywhere. They're punishing you people with real pain issues because of abusers actions. Which should be completely illegal. I guarantee anybody with more power than me could have these things inspected, and probably could win in a court setting. Someone with more power than me needs to stand up for us people with real pain issues. Facts!"

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128 Report
  • rocko
  • Taken for 2 to 5 years
  • December 13, 2014

Norco (acetaminophen / hydrocodone) for Back Pain "I did 6 years active duty with the army as an infantry soldier. I've been in the Iraq war in 2004, and the war in Afghanistan in 2006. During combat I've been in 6 IED explosions. A gun shot through my left shin, nerve damage to my whole right hand. Compressed 3 disc, and shattered 1 in my lower back. I have Traumatic brain injury which causes horrible migraines. I've been on everything since 2007...Oxycontin 80mg, 30mg Roxy's, 125mg fentanyl patches, morphine 60mgs, etc. Currently I'm on 10/325 Norco 6 times a day. I've grown dependent and tolerant to opiates. But Norco is by far the best medicine to make my chronic pain tolerable. And the side effects are close to none. I highly recommend this for chronic pain."

10 / 10
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199 Report
  • pain...
  • Taken for 10 years or more
  • April 27, 2014

For Rheumatoid Arthritis "I've had rheumatoid arthritis for 18 years with both hips and one knee replaced. I do very well and remain active on 5 Norco (10/325) in 24 hours. I rarely need it at night. Doctors are under pressure to reduce hydrocodone because they are prone to abuse. My doctor keeps trying to cut me back, first to 4 and next to 3. Nothing else works as well for me. It has less acetaminophen than Vicodin. I'm becoming depressed and less active because I can't control the pain. I wonder if others are experiencing this."

10 / 10
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207 Report
  • Fools...
  • Taken for 10 years or more
  • June 20, 2022

Norco (acetaminophen / hydrocodone) for Pain "Manufacturers of opioid pain relief medications must have gotten orders from healthcare leaders to reformulate these life saving medications. There is a recent drastic change in how they work and the cause most likely is they want you to ask for higher dosage to label you, which does no good due to the reformulate. Legitimate pain patients should just keep complaining to elected officials. Farmland states Dept. of Health may have different priorities because of the physical work needed for farm work. Bottom line, if you have daily pain because of a career in daily physical labor jobs with radiological images and medical proof of the pain condition, healthcare leaders couldn't care less."

2 / 10
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58 Report
  • Gandy...
  • Taken for 10 years or more
  • March 20, 2022

Norco (acetaminophen / hydrocodone) for Pain "Seems the physical dimensions of the product has changed with the formula. This med is supposed to be semi synthetic and may be less of the semi (natural opioid) and more of the cheap synthetic now. My same R/x that I have been taking for years, two a day max, fit in the smaller vial whereas 3 years ago they would not fit. They also do not have the same pain relief from that time. My heart disease is getting worse without the pain control. Please be cautious with this med if my suspicion is correct that the formula changed, because that cheap drugs are dangerous stuff. It is a shame how the medical community has changed and doesn't care about seniors who built all of what everyone enjoys today. Be safe policies are changing very fast."

2 / 10
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62 Report
  • LCano
  • September 15, 2018

Norco (acetaminophen / hydrocodone) for Pain "I used to take the 10/325 "yellow" pills, but now most pharmacies dispense white pills made by Watson, Mallinckrodt (“M”) or Amneal. Watson worked best for me, but not as well as the yellow pills. Walgreens just signed a contract with M and that's all they carry now. I can definitively say this past month has been awful. The M brand did not help my pain and made me very irritable. It's as if M put out a placebo or sugar pill. I refuse to take more pills due to the lack of efficacy of the M pills. I learned independent pharmacies often carry several brands at one time. One near me carries three -- including PAR (the yellow ones!) I hate to sound excited, but I thought they stopped making those and have been suffering through sub-par (pun intended) substitutions. The pharmacist told me Par costs twice as much to order than other brands. My guess is that's because it actually works. If you find a brand that works for your body, it can definitely improve quality of life."

9 / 10
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128 Report
  • MLB
  • Taken for 10 years or more
  • October 4, 2020

For Pain "Those with concerns regarding current generic pain medications are not imagining anything. After a gunshot left me with debilitating pain close to 20 years ago, I was hesitant to began opioid therapy. I was initially given numerous non-opiate meds to try and control the pain (Elavil, Neurontin, etc). After a few years, I ultimately ended up being prescribed Norco 10/325. Norco 10/325 worked wonders for me for years. All of a sudden, around the end of 2017, I filled my prescription and was notified that the pharmacy carries a new “manufacturer’s” brand. Ok, I thought no big deal, right? Well, it was a very big deal. That first generic I tried did zero except make me nauseous, so I changed pharmacies. The 2nd generic just made me feel weird & anxious. I stuck with the 3rd generic, Mallinckrodt, which is ok sometimes (very hit & miss, no stability). My physician has offered to prescribe me stronger meds, and despite my hesitation, I may need to change. Best of luck to you all!"

5 / 10
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88 Report
  • Jgano
  • Taken for 10 years or more
  • June 26, 2019

For Pain "I have 2 degrees in nursing and have been taking the yellow norco for well over 15 years. Sometimes I only take 1/2 pill and obtain relief. CVS has changed the manufacturer to lupin. Probably cheaper stockholders will be happy but I am not. Minimal pain relief I picked them up on the 22nd and am so angry. If I knew where I could get these generics analyzed I would do it. Now that I get NO pain relief and I have part d ins through CVS I will be dumping them during open enrolment and hopefully find one that is honorable. osteoarthritis SHAME on cvs !!"

1 / 10
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110 Report
  • Krissy
  • June 13, 2019

Norco (acetaminophen / hydrocodone) for Back Pain "I was injured years ago badly. When I fell it worsened & had surgery. My pain is severe & classified intractable. PT helps but my back pain persists. I tried Percocet, morphine & Hysingla but nothing touched the pain. It was as if I hadn’t taken anything! I was taking too many Advil a day which helped but Dr said that’s very dangerous. I gave up & she suggested 1 last med Norco. I was skeptical & given in to the pain but took just one pill & after 1 hour, I had no pain for hours! I’ve had excruciating pain for so long, it honestly feels strange not to have it a few hours a day now. Another plus is NO SIDE EFFECTS like others (dizziness, out of it feeling (I guess euphoria which I hate), no constipation) and it just works! Husband sees a difference in my outlook and how I’m walking better. There’s need for 2nd pill midday when the morning 1 wears off then some pain at night. But I’m ok with pain at night because I’m just resting. I’m finally getting my life back. I really just can’t believe it!!!!"

9 / 10
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110 Report
  • Enough
  • Taken for 1 to 2 years
  • June 15, 2022

Norco (acetaminophen / hydrocodone) for Rheumatoid Arthritis "Have taken Norco 10/325 for years, for spinal stenosis and injured vertebrae pain. Within the last few years, generic was fine, and now, it has been tainted with who knows what. Amneal and Lupin pharmaceutical companies are two of the worst rubbish generic Norco. Getting away with selling poison, that doesn’t work. Watson, was one that did. What happened? The aforementioned should be investigated."

1 / 10
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54 Report
  • mbeau
  • February 24, 2019

For Pain "I truly believe the FDA and the pharmaceutical companies are working together to make our hydrocodone pills less effective. I have been taking two 10/325 hydrocodone pills per day for the last several years since I have psoriatic arthritis. At first I was able to get the yellow Par pills and they worked really great! When I moved to FL, I could only get the Watson brand and they worked pretty well. In Sept 2018 Walgreens switched to TRIS and they are horrible. Then I tried the Mallinckrodt from WalMart and they're worthless. Then 3 months ago I tried Aurobindo from Costco and found then to work pretty well. However, I picked up my latest prescription on Thursday and they must have changed the ingredients as now they offer no pain relief at all. I agree with the folks who have written that we need to complain to the FDA concerning the quality of the hydrocodone pills we are receiving. This is extremely upsetting that there isn't one single brand available to help with our pain!"

2 / 10
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113 Report
  • Realt...
  • Taken for 2 to 5 years
  • April 3, 2019

For Pain "My pain issues are Severe Congenital Spinal Stenosis of Cervical,and lumbar,Degenerative Disc Disease,Scoliosis, & peripheral neuropathy. The stenosis causing my spine to flatten. I'm new to writing reviews, so please bear with me. My pain management Dr prescribed Norco 10/325. I've always received the brand Lupin Pharmaceuticals which relieve my pain tremendously. Until recently I was given Amneal Pharm, and today Mallinckrodt Pharm both from my CVS Pharmacy. These 2 Companies are distributing trash! If I were to submit Lupin Pharmaceuticals Norco, Amneal, & Mallinckrodt to a chemist he/she would respond with the same results. Those Companies Amneal, & Mallinckrodt are using some type of fillers that has caused their pain medication to be worse than a baby aspirin! It shouldn't matter what company manufactures Norco. They should all be the same, however that's not the case! They'll end up causing people to take more than prescribed, because there's no pain relief! Quit screwing with pain medication! How do these people sleep at night knowing their product is JUNK! THANK YOU LUPIN PHARMECEUTICALS FOR NOT BEING PART OF THE MONOPOLY THE GOVERNMENT HAS CREATED FOR PATIENTS WITH CHRONIC PAIN!"

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111 Report
  • Jones
  • Taken for 5 to 10 years
  • June 21, 2019

For Back Pain "Me Arthritis, torn L3, neck nerve damage, sciatica, bullet in leg lodged between the nerve/bone. Recently had spinal fusion surgery, titanium rods inserted in spine. Taking percocet 10/325 and Norco 10/325 for break-thru pain. the MANUFACTURER DOES MATTER. I made it CLEAR to pharmacist will only take Endocet MANUFACTURER with the percocet and EYWA MANUFACTURER for the norco. Wont leave pharmacy until I check. Comments about manufacturer's, you are NOT crazy or imagining things. These foreign discounted suppliers are causing problems hard working, tax paying TRUE PAIN SUFFERERS like us with their knock off brands. We ALL need to write the FDA and get a petition going. Not to mention the addicts that want to shoot and snort these pills then again WE SUFFER! I have a great dr & pharmacist thank God that knows MY PAIN IS REAL an my medication lasts me from one appt to the next, random urine tests proves it. To my family of pain suffers, may we ALL have long lasting relief very soon! MRS. JONES"

7 / 10
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  • KTano
  • Taken for 2 to 5 years
  • April 26, 2021

For Pain "I have been taking 5/325 mg and on occasion 7.5/325 mg generic Norco. I changed pharmacy one time and was given Mallinckrodt Pharmaceuticals brand (M366 on pill). I have had some psychological disturbances since starting this current round of meds from this company. Not sure if it is coincidence but I am extremely concerned!!! Someone, anyone who reads these reviews, can we investigate this company? I see other people have mentioned this as well. What is going on? Thank you."

7 / 10
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75 Report
  • EddieZ
  • Taken for 10 years or more
  • January 9, 2022

For Pain "Full Stop. Do not complain here or with your physician. Send a FDA MEDWatch Complaint form 3500 and FAX it to the FDA. Only and only if we have enough complaints will the FDA actually run an assay to establish the FDA required 80-120% of a Brand medication value. We all know that the medication we are receiving is sub therapeutic and not one person is listening. The only way we can get relief for REAL Pain patients is to keep sending the Medwatch FDA form 3500 to the government. FDA/Medwatch/3500 form and print and fax. Do it now!!!"

1 / 10
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61 Report
  • Dave
  • Taken for 2 to 5 years
  • January 4, 2019

Norco (acetaminophen / hydrocodone) for Back Pain "I switched from rite aid and the useless mallinckrodt (malincrap) brand to an independent pharmacy that sells the yellow 3601 Norco in October. I couldn't believe it but I only need 2 a day to control my pain. The next 3 months the same yellow Norco had decreased in pain relief to the point that my most recent script was total garbage. Same pills but different shipment. Complained to pharmacy and now I'm filing complaint with the FDA. People must file written complaints for the FDA TO INVESTIGATE. PHAR P thats the brand."

2 / 10
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112 Report
  • Drew
  • Taken for 10 years or more
  • June 13, 2023

Norco (acetaminophen / hydrocodone) for Pain "I used to take the colored Watson Norco and it worked great but ever since they switched to this white generic one it doesn’t do anything for me and has been the same for friends. The Percocet still works but not the hydrocodone."

3 / 10
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30 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.